Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system.

Wafai, Razan; Williams, Elizabeth D; de Souza, Emma; Simpson, Peter T; McCart Reed, Amy E; Kutasovic, Jamie R; Waltham, Mark; Snell, Cameron E; Blick, Tony; Thompson, Erik W; Hugo, Honor J

Wafai, Razan; Williams, Elizabeth D; de Souza, Emma; Simpson, Peter T; McCart Reed, Amy E; Kutasovic, Jamie R; Waltham, Mark; Snell, Cameron E; Blick, Tony; Thompson, Erik W; Hugo, Honor J.

Afiliação

Wafai R; Invasion and Metastasis Unit, St. Vincent's Institute, Melbourne, VIC, Australia.
Williams ED; Department of Surgery, The University of Melbourne, St. Vincent's Hospital, Melbourne, VIC, Australia.
de Souza E; Invasion and Metastasis Unit, St. Vincent's Institute, Melbourne, VIC, Australia.
Simpson PT; Department of Surgery, The University of Melbourne, St. Vincent's Hospital, Melbourne, VIC, Australia.
McCart Reed AE; Queensland University of Technology, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Brisbane, QLD, Australia.
Kutasovic JR; Translational Research Institute, Brisbane, QLD, Australia.
Waltham M; Australian Prostate Cancer Research Centre-Queensland and Queensland Bladder Cancer Initiative, Brisbane, QLD, Australia.
Snell CE; Department of Surgery, The University of Melbourne, St. Vincent's Hospital, Melbourne, VIC, Australia.
Blick T; The Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.
Thompson EW; Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Hugo HJ; Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.

Breast Cancer Res ; 22(1): 136, 2020 12 04.

Article em En | MEDLINE | ID: mdl-33276802

Assuntos

Neoplasias Ósseas/genética; Neoplasias da Mama/genética; Carcinoma Ductal de Mama/genética; Transição Epitelial-Mesenquimal/genética; Integrina alfa2/genética; Integrina beta1/genética; Adulto; Animais; Neoplasias Ósseas/secundário; Mama/patologia; Neoplasias da Mama/patologia; Carcinoma Ductal de Mama/secundário; Linhagem Celular Tumoral; Movimento Celular/genética; Feminino; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Humanos; Camundongos; Proteínas Serina-Treonina Quinases/genética; Regulação para Cima; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Breast cancer; EMT; Hypoxia; Integrin; Patient-derived xenograft (PDX); Twist1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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