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Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Merlini, Mario; Rafalski, Victoria A; Ma, Keran; Kim, Keun-Young; Bushong, Eric A; Rios Coronado, Pamela E; Yan, Zhaoqi; Mendiola, Andrew S; Sozmen, Elif G; Ryu, Jae Kyu; Haberl, Matthias G; Madany, Matthew; Sampson, Daniel Naranjo; Petersen, Mark A; Bardehle, Sophia; Tognatta, Reshmi; Dean, Terry; Acevedo, Rosa Meza; Cabriga, Belinda; Thomas, Reuben; Coughlin, Shaun R; Ellisman, Mark H; Palop, Jorge J; Akassoglou, Katerina.
Afiliação
  • Merlini M; Gladstone Institutes, San Francisco, CA, USA.
  • Rafalski VA; Gladstone Institutes, San Francisco, CA, USA.
  • Ma K; Gladstone Institutes, San Francisco, CA, USA.
  • Kim KY; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Bushong EA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
  • Rios Coronado PE; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Yan Z; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
  • Mendiola AS; Gladstone Institutes, San Francisco, CA, USA.
  • Sozmen EG; Gladstone Institutes, San Francisco, CA, USA.
  • Ryu JK; Gladstone Institutes, San Francisco, CA, USA.
  • Haberl MG; Gladstone Institutes, San Francisco, CA, USA.
  • Madany M; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
  • Sampson DN; Gladstone Institutes, San Francisco, CA, USA.
  • Petersen MA; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
  • Bardehle S; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Tognatta R; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
  • Dean T; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Acevedo RM; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
  • Cabriga B; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Thomas R; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
  • Coughlin SR; Gladstone Institutes, San Francisco, CA, USA.
  • Ellisman MH; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
  • Palop JJ; Gladstone Institutes, San Francisco, CA, USA.
  • Akassoglou K; Gladstone Institutes, San Francisco, CA, USA.
Nat Neurosci ; 24(1): 19-23, 2021 01.
Article em En | MEDLINE | ID: mdl-33318667
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating MgPTX mice to genetically inhibit Gi in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article