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Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng, Fangda; Edison, Paul.
Afiliação
  • Leng F; Department of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.
  • Edison P; Department of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK. paul.edison@imperial.ac.uk.
Nat Rev Neurol ; 17(3): 157-172, 2021 03.
Article em En | MEDLINE | ID: mdl-33318676
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated to contribute 60-70% of all cases of dementia worldwide. According to the prevailing amyloid cascade hypothesis, amyloid-ß (Aß) deposition in the brain is the initiating event in AD, although evidence is accumulating that this hypothesis is insufficient to explain many aspects of AD pathogenesis. The discovery of increased levels of inflammatory markers in patients with AD and the identification of AD risk genes associated with innate immune functions suggest that neuroinflammation has a prominent role in the pathogenesis of AD. In this Review, we discuss the interrelationships between neuroinflammation and amyloid and tau pathologies as well as the effect of neuroinflammation on the disease trajectory in AD. We specifically focus on microglia as major players in neuroinflammation and discuss the spatial and temporal variations in microglial phenotypes that are observed under different conditions. We also consider how these cells could be modulated as a therapeutic strategy for AD.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article