Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data.

Liu, Huolong; Meyer, Robert; Flamm, Matthew; Wareham, Laura; Metzger, Matthew; Tantuccio, Anthony; Yoon, Seongkyu

Liu, Huolong; Meyer, Robert; Flamm, Matthew; Wareham, Laura; Metzger, Matthew; Tantuccio, Anthony; Yoon, Seongkyu.

Afiliação

Liu H; Department of Chemical Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, Massachusetts, 01854, USA.
Meyer R; Pharmaceutical Commercialization Technology, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Flamm M; Applied Mathematics and Modeling, Scientific Modeling Platforms, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Wareham L; Pharmaceutical Commercialization Technology, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Metzger M; Pharmaceutical Commercialization Technology, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Tantuccio A; Pharmaceutical Commercialization Technology, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Yoon S; Department of Chemical Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, Massachusetts, 01854, USA. Seongkyu_Yoon@uml.edu.

AAPS PharmSciTech ; 22(1): 17, 2021 Jan 03.

Article em En | MEDLINE | ID: mdl-33389197

Assuntos

Composição de Medicamentos/métodos; Comprimidos; Modelos Estatísticos; Projetos Piloto; Temperatura

Palavras-chave

Coating efficiency; Coating uniformity; Design of experiment (DoE); Design space; Pharmaceutical manufacturing; Quality by design (QbD); Tablet film coating; Tablet moisture content

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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