Photo-driven self-powered biosensors for ultrasensitive microRNA detection based on metal-organic framework-controlled release behavior.
Analyst
; 146(3): 816-819, 2021 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-33393565
ABSTRACT
We developed a "signal-on" self-powered biosensing strategy by taking full advantage of both photoelectrochemical biofuel cells (PBFCs) and metal-organic framework (MOF)-controlled release behavior for ultrasensitive microRNA assay. PBFC-based self-powered sensors have the unique characteristics of non-requirement of external power sources, simple fabrication process, miniature size, good anti-interference ability and low cost. Furthermore, based on the target microRNA-induced release of the electron donor ascorbic acid and the high catalytic ability of the biocathode to catalyse the oxygen reduction reaction, photo-driven self-powered biosensors for ultrasensitive microRNA detection were successfully realized. The as-proposed signal-on biosensor not only provides a simple and effective strategy, but also possesses the merits of a wide dynamic concentration response range and high sensitivity for microRNA detection, with a limit of detection down to 0.16 fM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article