Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes.

Wang, Lei; Yi, Jia; Lu, Ling-Yun; Zhang, Yue-Ying; Wang, Lan; Hu, Guo-Sheng; Liu, Yi-Chen; Ding, Jian-Cheng; Shen, Hai-Feng; Zhao, Fang-Qing; Huang, Hai-Hua; Liu, Wen

Wang, Lei; Yi, Jia; Lu, Ling-Yun; Zhang, Yue-Ying; Wang, Lan; Hu, Guo-Sheng; Liu, Yi-Chen; Ding, Jian-Cheng; Shen, Hai-Feng; Zhao, Fang-Qing; Huang, Hai-Hua; Liu, Wen.

Afiliação

Wang L; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Yi J; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Lu LY; Department of Orthopedics, The Fifth Hospital of Xiamen, Xiamen, Fujian 361101, China.
Zhang YY; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Wang L; Department of Pathology, The Second Affiliated Hospital, Shantou University Medical College, Dongxia North Road, Shantou, Guangdong 515041, China.
Hu GS; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Liu YC; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Ding JC; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Shen HF; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Zhao FQ; Computational Genomics Lab, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Huang HH; Department of Pathology, The Second Affiliated Hospital, Shantou University Medical College, Dongxia North Road, Shantou, Guangdong 515041, China.
Liu W; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.

Theranostics ; 11(4): 1732-1752, 2021.

Article em En | MEDLINE | ID: mdl-33408778

Assuntos

Biomarcadores Tumorais/metabolismo; Neoplasias da Mama/patologia; Proteínas de Ciclo Celular/metabolismo; Estrogênios/farmacologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; RNA Circular/genética; Receptores de Progesterona/genética; Animais; Apoptose; Biomarcadores Tumorais/genética; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Ciclo Celular; Proteínas de Ciclo Celular/genética; Proliferação de Células; Feminino; Perfilação da Expressão Gênica; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; MicroRNAs/genética; Prognóstico; Receptores de Estrogênio/genética; Receptores de Estrogênio/metabolismo; Taxa de Sobrevida; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

ER-positive breast cancer; cell cycle; circRNA; estrogen and estrogen receptor; miRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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