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The differential impact of pediatric COVID-19 between high-income countries and low- and middle-income countries: A systematic review of fatality and ICU admission in children worldwide.
Kitano, Taito; Kitano, Mao; Krueger, Carsten; Jamal, Hassan; Al Rawahi, Hatem; Lee-Krueger, Rachelle; Sun, Rose Doulin; Isabel, Sandra; García-Ascaso, Marta Taida; Hibino, Hiromi; Camara, Bettina; Isabel, Marc; Cho, Leanna; Groves, Helen E; Piché-Renaud, Pierre-Philippe; Kossov, Michael; Kou, Ikuho; Jon, Ilsu; Blanchard, Ana C; Matsuda, Nao; Mahood, Quenby; Wadhwa, Anupma; Bitnun, Ari; Morris, Shaun K.
Afiliação
  • Kitano T; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Kitano M; Mikage Child Dental Clinic, Kobe, Hyogo, Japan.
  • Krueger C; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Jamal H; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Al Rawahi H; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Lee-Krueger R; Faculty of Education, University of Ottawa, Ottawa, ON, Canada.
  • Sun RD; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Isabel S; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • García-Ascaso MT; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Hibino H; McEwen Stem Cell Institute, Universal Health Network, Toronto, ON, Canada.
  • Camara B; Faculty of Immunology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Isabel M; Département de mathématique, Faculté des sciences et génie, Université Laval, Pavillon Alexandre-Vachon, Québec, QC, Canada.
  • Cho L; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Groves HE; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Piché-Renaud PP; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Kossov M; Department Laboratory Medicine and Pathobiology, Division of Medical Microbiology, The Hospital for Sick Children at University of Toronto, Toronto, ON, Canada.
  • Kou I; Kaji Dental Clinic, Kobe, Hyogo, Japan.
  • Jon I; Utsunomiya Kyoritsu Clinic, Utsunomiya, Tochigi, Japan.
  • Blanchard AC; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Matsuda N; Alpaca Child Dental Clinic, Hiroshima, Hiroshima, Japan.
  • Mahood Q; Hospital Library and Archives, Learning Institute, The Hospital for Sick Children at University of Toronto, Toronto, ON, Canada.
  • Wadhwa A; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Bitnun A; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Morris SK; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
PLoS One ; 16(1): e0246326, 2021.
Article em En | MEDLINE | ID: mdl-33513204
BACKGROUND: The overall global impact of COVID-19 in children and regional variability in pediatric outcomes are presently unknown. METHODS: To evaluate the magnitude of global COVID-19 death and intensive care unit (ICU) admission in children aged 0-19 years, a systematic review was conducted for articles and national reports as of December 7, 2020. This systematic review is registered with PROSPERO (registration number: CRD42020179696). RESULTS: We reviewed 16,027 articles as well as 225 national reports from 216 countries. Among the 3,788 global pediatric COVID-19 deaths, 3,394 (91.5%) deaths were reported from low- and middle-income countries (LMIC), while 83.5% of pediatric population from all included countries were from LMIC. The pediatric deaths/1,000,000 children and case fatality rate (CFR) were significantly higher in LMIC than in high-income countries (HIC) (2.77 in LMIC vs 1.32 in HIC; p < 0.001 and 0.24% in LMIC vs 0.01% in HIC; p < 0.001, respectively). The ICU admission/1,000,000 children was 18.80 and 1.48 in HIC and LMIC, respectively (p < 0.001). The highest deaths/1,000,000 children and CFR were in infants < 1 year old (10.03 and 0.58% in the world, 5.39 and 0.07% in HIC and 10.98 and 1.30% in LMIC, respectively). CONCLUSIONS: The study highlights that there may be a larger impact of pediatric COVID-19 fatality in LMICs compared to HICs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Systematic_reviews Limite: Child / Child, preschool / Humans / Infant / Newborn Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Systematic_reviews Limite: Child / Child, preschool / Humans / Infant / Newborn Idioma: En Ano de publicação: 2021 Tipo de documento: Article