Local Stabilization of Hypoxia-Inducible Factor-1&#945; Controls Intestinal Inflammation <i>via</i> Enhanced Gut Barrier Function and Immune Regulation.

Kim, Young-In; Yi, Eun-Je; Kim, Young-Dae; Lee, A Reum; Chung, Jiwoung; Ha, Hae Chan; Cho, Joong Myung; Kim, Seong-Ryeol; Ko, Hyun-Jeong; Cheon, Jae-Hee; Hong, Yong Rae; Chang, Sun-Young

Local Stabilization of Hypoxia-Inducible Factor-1α Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation.

Kim, Young-In; Yi, Eun-Je; Kim, Young-Dae; Lee, A Reum; Chung, Jiwoung; Ha, Hae Chan; Cho, Joong Myung; Kim, Seong-Ryeol; Ko, Hyun-Jeong; Cheon, Jae-Hee; Hong, Yong Rae; Chang, Sun-Young.

Afiliação

Kim YI; Laboratory of Microbiology, College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, South Korea.
Yi EJ; Laboratory of Microbiology, College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, South Korea.
Kim YD; Institute for Drug Discovery, CrystalGenomics, Inc., Seongnam-si, South Korea.
Lee AR; Institute for Drug Discovery, CrystalGenomics, Inc., Seongnam-si, South Korea.
Chung J; Institute for Drug Discovery, CrystalGenomics, Inc., Seongnam-si, South Korea.
Ha HC; Institute for Drug Discovery, CrystalGenomics, Inc., Seongnam-si, South Korea.
Cho JM; Institute for Drug Discovery, CrystalGenomics, Inc., Seongnam-si, South Korea.
Kim SR; Laboratory of Microbiology and Immunology, Department of Pharmacy, Kangwon National University, Chuncheon-si, South Korea.
Ko HJ; Laboratory of Microbiology and Immunology, Department of Pharmacy, Kangwon National University, Chuncheon-si, South Korea.
Cheon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea.
Hong YR; Institute for Drug Discovery, CrystalGenomics, Inc., Seongnam-si, South Korea.
Chang SY; Laboratory of Microbiology, College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, South Korea.

Front Immunol ; 11: 609689, 2020.

Article em En | MEDLINE | ID: mdl-33519819

Assuntos

Subunidade alfa do Fator 1 Induzível por Hipóxia/imunologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Inflamação/imunologia; Inflamação/metabolismo; Mucosa Intestinal/imunologia; Mucosa Intestinal/metabolismo; Animais; Células CACO-2; Linhagem Celular Tumoral; Colite/tratamento farmacológico; Colite/imunologia; Colite/metabolismo; Citocinas/imunologia; Citocinas/metabolismo; Modelos Animais de Doenças; Feminino; Células HCT116; Células HeLa; Humanos; Hipóxia/tratamento farmacológico; Hipóxia/imunologia; Hipóxia/metabolismo; Doenças Inflamatórias Intestinais/tratamento farmacológico; Doenças Inflamatórias Intestinais/imunologia; Doenças Inflamatórias Intestinais/metabolismo; Mucosa Intestinal/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos ICR; Inibidores de Prolil-Hidrolase/farmacologia; Fator Trefoil-3/imunologia; Fator Trefoil-3/metabolismo

Palavras-chave

gut barrier; hypoxia-inducible factor; immune regulation; inflammatory bowel disease; prolyl hydroxylase inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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