Tonsillectomy and the subsequent risk of psoriasis: A nationwide population-based cohort study.
J Am Acad Dermatol
; 85(6): 1493-1502, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-33548305
ABSTRACT
BACKGROUND:
Tonsillectomy has been suggested as an intervention to resolve psoriasis.OBJECTIVE:
This study aimed to investigate the subsequent risk of psoriasis in patients who received tonsillectomy.METHODS:
We used data from the Taiwan National Health Insurance Research Database. The tonsillectomy group (case group) and the tonsillectomy-free group (comparison group) were matched at a ratio of 14 by demographic data, comorbidities, medical confounders, and the index date. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS:
We identified 2021 patients as the case group and matched 8084 individuals as the comparison group. The adjusted HR (aHR) of psoriasis was 0.43 (95% CI, 0.22-0.87; P < .05). The study population is composed of a mainly male (65%) and young population (mostly younger than 50 years). Notably, patients with rheumatoid arthritis increased the risk of psoriasis (aHR, 3.97; 95% CI, 1.17-13.48; P < .05). In our stratification analysis, the risk of psoriasis decreased in almost all subgroups.LIMITATION:
Our database did not include information on genome and the subtypes of psoriasis.CONCLUSION:
Our study showed a decreased risk of psoriasis in the tonsillectomy group after adjustment for baseline characteristics, comorbidities, and medical confounders compared with the reference group.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article