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Lasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection.
Jiang, Xiao-Lin; Wang, Guo-Lin; Zhao, Xiang-Na; Yan, Fei-Hu; Yao, Lin; Kou, Zeng-Qiang; Ji, Sheng-Xiang; Zhang, Xiao-Li; Li, Cun-Bao; Duan, Li-Jun; Li, Yan; Zhang, Yu-Wen; Duan, Qing; Wang, Tie-Cheng; Li, En-Tao; Wei, Xiao; Wang, Qing-Yang; Wang, Xue-Feng; Sun, Wei-Yang; Gao, Yu-Wei; Kang, Dian-Min; Zhang, Ji-Yan; Ma, Mai-Juan.
Afiliação
  • Jiang XL; Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Wang GL; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Zhao XN; Institute of Disease Control and Prevention, Chinese People's Liberation Army, Beijing, China.
  • Yan FH; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, China.
  • Yao L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Kou ZQ; Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Ji SX; Linyi Center for Disease Control and Prevention, Linyi, China.
  • Zhang XL; Linyi Center for Disease Control and Prevention, Linyi, China.
  • Li CB; Linyi Center for Disease Control and Prevention, Linyi, China.
  • Duan LJ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Li Y; Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Zhang YW; Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Duan Q; Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Wang TC; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, China.
  • Li ET; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, China.
  • Wei X; Institute of Disease Control and Prevention, Chinese People's Liberation Army, Beijing, China.
  • Wang QY; Beijing Institute of Brain Science, Beijing, China.
  • Wang XF; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, China.
  • Sun WY; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, China.
  • Gao YW; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, China.
  • Kang DM; Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Zhang JY; Beijing Institute of Brain Science, Beijing, China. jiyanzhang@hotmail.com.
  • Ma MJ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. mjma@163.com.
Nat Commun ; 12(1): 897, 2021 02 09.
Article em En | MEDLINE | ID: mdl-33563974
The dynamics, duration, and nature of immunity produced during SARS-CoV-2 infection are still unclear. Here, we longitudinally measured virus-neutralising antibody, specific antibodies against the spike (S) protein, receptor-binding domain (RBD), and the nucleoprotein (N) of SARS-CoV-2, as well as T cell responses, in 25 SARS-CoV-2-infected patients up to 121 days post-symptom onset (PSO). All patients seroconvert for IgG against N, S, or RBD, as well as IgM against RBD, and produce neutralising antibodies (NAb) by 14 days PSO, with the peak levels attained by 15-30 days PSO. Anti-SARS-CoV-2 IgG and NAb remain detectable and relatively stable 3-4 months PSO, whereas IgM antibody rapidly decay. Approximately 65% of patients have detectable SARS-CoV-2-specific CD4+ or CD8+ T cell responses 3-4 months PSO. Our results thus provide critical evidence that IgG, NAb, and T cell responses persist in the majority of patients for at least 3-4 months after infection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article