Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help.

Merino Tejero, Elena; Lashgari, Danial; García-Valiente, Rodrigo; Gao, Xuefeng; Crauste, Fabien; Robert, Philippe A; Meyer-Hermann, Michael; Martínez, María Rodríguez; van Ham, S Marieke; Guikema, Jeroen E J; Hoefsloot, Huub; van Kampen, Antoine H C

Merino Tejero, Elena; Lashgari, Danial; García-Valiente, Rodrigo; Gao, Xuefeng; Crauste, Fabien; Robert, Philippe A; Meyer-Hermann, Michael; Martínez, María Rodríguez; van Ham, S Marieke; Guikema, Jeroen E J; Hoefsloot, Huub; van Kampen, Antoine H C.

Afiliação

Merino Tejero E; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Lashgari D; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
García-Valiente R; Bioinformatics Laboratory, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Gao X; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.
Crauste F; Université de Paris, CNRS, MAP5 UMR 8145, Paris, France.
Robert PA; Department for Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Meyer-Hermann M; Department for Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Martínez MR; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany.
van Ham SM; IBM Research Europe, Zürich, Switzerland.
Guikema JEJ; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Hoefsloot H; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
van Kampen AHC; Department of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam University Medical Centers, Amsterdam, Netherlands.

Front Immunol ; 11: 620716, 2020.

Article em En | MEDLINE | ID: mdl-33613551

Assuntos

Linfócitos B/imunologia; Antígenos CD40/imunologia; Simulação por Computador; Centro Germinativo/imunologia; Memória Imunológica/imunologia; Linfopoese/imunologia; Modelos Imunológicos; Plasmócitos/imunologia; Células T Auxiliares Foliculares/imunologia; Divisão Celular Assimétrica; Linfócitos B/citologia; Linhagem da Célula; Redes Reguladoras de Genes; Centro Germinativo/citologia; Humanos; Fatores Reguladores de Interferon/genética; Fatores Reguladores de Interferon/fisiologia; Plasmócitos/citologia; Fator 1 de Ligação ao Domínio I Regulador Positivo/genética; Fator 1 de Ligação ao Domínio I Regulador Positivo/fisiologia; Proteínas Proto-Oncogênicas c-bcl-6/genética; Proteínas Proto-Oncogênicas c-bcl-6/fisiologia; Transdução de Sinais; Fatores de Tempo

Palavras-chave

CD40 signaling; T follicular helper cell; germinal center; multiscale model; plasma cell differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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