Computational modeling of malignant ascites reveals CCL5-SDC4 interaction in the immune microenvironment of ovarian cancer.

Kim, Soochi; Han, Youngjin; Kim, Se Ik; Lee, Juwon; Jo, HyunA; Wang, Wenyu; Cho, Untack; Park, Woong-Yang; Rando, Thomas A; Dhanasekaran, Danny N; Song, Yong Sang

Kim, Soochi; Han, Youngjin; Kim, Se Ik; Lee, Juwon; Jo, HyunA; Wang, Wenyu; Cho, Untack; Park, Woong-Yang; Rando, Thomas A; Dhanasekaran, Danny N; Song, Yong Sang.

Afiliação

Kim S; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, California, USA.
Han Y; Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Kim SI; WCU Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Lee J; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jo H; Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Wang W; WCU Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Cho U; Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Park WY; WCU Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Rando TA; Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Dhanasekaran DN; Interdisciplinary Program in Cancer Biology, Seoul National University, Seoul, Republic of Korea.
Song YS; Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea.

Mol Carcinog ; 60(5): 297-312, 2021 05.

Article em En | MEDLINE | ID: mdl-33721368

Assuntos

Ascite/patologia; Quimiocina CCL5/genética; Quimiocina CCL5/metabolismo; Neoplasias Ovarianas/mortalidade; Sindecana-4/genética; Sindecana-4/metabolismo; Ascite/metabolismo; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Polaridade Celular; Progressão da Doença; Feminino; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Humanos; Células Matadoras Naturais/metabolismo; Macrófagos/metabolismo; Pessoa de Meia-Idade; Modelos Teóricos; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo; Prognóstico; Análise de Sequência de RNA; Análise de Célula Única/métodos; Análise de Sobrevida; Linfócitos T/metabolismo; Microambiente Tumoral

Palavras-chave

ascites; intercellular communication; ovarian cancer; single-cell RNA-seq; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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