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Cingulo-opercular control network and disused motor circuits joined in standby mode.
Newbold, Dillan J; Gordon, Evan M; Laumann, Timothy O; Seider, Nicole A; Montez, David F; Gross, Sarah J; Zheng, Annie; Nielsen, Ashley N; Hoyt, Catherine R; Hampton, Jacqueline M; Ortega, Mario; Adeyemo, Babatunde; Miller, Derek B; Van, Andrew N; Marek, Scott; Schlaggar, Bradley L; Carter, Alexandre R; Kay, Benjamin P; Greene, Deanna J; Raichle, Marcus E; Petersen, Steven E; Snyder, Abraham Z; Dosenbach, Nico U F.
Afiliação
  • Newbold DJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110; newbold@wustl.edu ndosenbach@wustl.edu.
  • Gordon EM; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
  • Laumann TO; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
  • Seider NA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Montez DF; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Gross SJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
  • Zheng A; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Nielsen AN; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Hoyt CR; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Hampton JM; Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL 60611.
  • Ortega M; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110.
  • Adeyemo B; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
  • Miller DB; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Van AN; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Marek S; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Schlaggar BL; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Carter AR; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110.
  • Kay BP; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Greene DJ; Kennedy Krieger Institute, Baltimore, MD 21205.
  • Raichle ME; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
  • Petersen SE; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
  • Snyder AZ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
  • Dosenbach NUF; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110.
Proc Natl Acad Sci U S A ; 118(13)2021 03 30.
Article em En | MEDLINE | ID: mdl-33753484
Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article