Extracellular vesicle-derived microRNA-18b ameliorates preeclampsia by enhancing trophoblast proliferation and migration via Notch2/TIM3/mTORC1 axis.

Yang, Zhongmei; Shan, Nan; Deng, Qinyin; Wang, Yujue; Hou, Yan; Mei, Jie; Wu, Zhao

Yang, Zhongmei; Shan, Nan; Deng, Qinyin; Wang, Yujue; Hou, Yan; Mei, Jie; Wu, Zhao.

Afiliação

Yang Z; Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Shan N; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Deng Q; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wang Y; Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Hou Y; Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Mei J; Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Wu Z; Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

J Cell Mol Med ; 25(10): 4583-4595, 2021 05.

Article em En | MEDLINE | ID: mdl-33835684

Assuntos

Vesículas Extracelulares/genética; Regulação da Expressão Gênica; Receptor Celular 2 do Vírus da Hepatite A/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; MicroRNAs/genética; Pré-Eclâmpsia/prevenção & controle; Receptor Notch2/metabolismo; Animais; Apoptose; Movimento Celular; Proliferação de Células; Feminino; Receptor Celular 2 do Vírus da Hepatite A/genética; Humanos; Alvo Mecanístico do Complexo 1 de Rapamicina/genética; Células-Tronco Mesenquimais/metabolismo; Células-Tronco Mesenquimais/patologia; Pré-Eclâmpsia/genética; Pré-Eclâmpsia/metabolismo; Pré-Eclâmpsia/patologia; Gravidez; Ratos; Ratos Sprague-Dawley; Receptor Notch2/genética; Trofoblastos/metabolismo; Trofoblastos/patologia; Células Tumorais Cultivadas; Cordão Umbilical/metabolismo; Cordão Umbilical/patologia

Palavras-chave

MicroRNA-18b; Rapamycin complex 1; T-cell immunoglobulin and mucin domain-containing protein 3; extracellular vesicle; migration; notch receptor 2; preeclampsia; proliferation; trophoblast

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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