Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing.

Park-Holohan, So-Jin; Brunello, Elisabetta; Kampourakis, Thomas; Rees, Martin; Irving, Malcolm; Fusi, Luca

Park-Holohan, So-Jin; Brunello, Elisabetta; Kampourakis, Thomas; Rees, Martin; Irving, Malcolm; Fusi, Luca.

Afiliação

Park-Holohan SJ; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and British Heart Foundation Centre of Research Excellence, King's College London, SE1 1UL London, United Kingdom.
Brunello E; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and British Heart Foundation Centre of Research Excellence, King's College London, SE1 1UL London, United Kingdom.
Kampourakis T; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and British Heart Foundation Centre of Research Excellence, King's College London, SE1 1UL London, United Kingdom.
Rees M; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and British Heart Foundation Centre of Research Excellence, King's College London, SE1 1UL London, United Kingdom.
Irving M; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and British Heart Foundation Centre of Research Excellence, King's College London, SE1 1UL London, United Kingdom.
Fusi L; Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and British Heart Foundation Centre of Research Excellence, King's College London, SE1 1UL London, United Kingdom luca.fusi@kcl.ac.uk.

Proc Natl Acad Sci U S A ; 118(16)2021 04 20.

Article em En | MEDLINE | ID: mdl-33850019

Assuntos

Miocárdio/metabolismo; Miosinas/metabolismo; Estresse Fisiológico/fisiologia; Citoesqueleto de Actina/metabolismo; Animais; Cálcio/metabolismo; Citoesqueleto/metabolismo; Coração/fisiologia; Masculino; Mecanotransdução Celular/fisiologia; Contração Muscular; Cadeias Leves de Miosina/metabolismo; Miosinas/fisiologia; Ratos; Ratos Wistar; Sarcômeros/metabolismo; Transdução de Sinais

Palavras-chave

heart muscle; muscle regulation; myosin motor; myosin-binding protein C

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article