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Targeting Nanostrategies for Imaging of Atherosclerosis.
Costagliola di Polidoro, Angela; Grassia, Agnese; De Sarno, Francesca; Bevilacqua, Paolo; Mollo, Valentina; Romano, Eugenia; Di Taranto, Maria Donata; Fortunato, Giuliana; Bracale, Umberto Marcello; Tramontano, Liberatore; Diomaiuti, Tommaso Claudio; Torino, Enza.
Afiliação
  • Costagliola di Polidoro A; Department of Chemical, Materials Engineering & Industrial Production, University of Naples Federico II, Piazzale Tecchio 80, Naples 80125, Italy.
  • Grassia A; Center for Advanced Biomaterials for Health Care (CABHC), Fondazione Istituto Italiano di Tecnologia (IIT)CRIB, Largo Barsanti e Matteucci 53, Naples 80125, Italy.
  • De Sarno F; Department of Chemical, Materials Engineering & Industrial Production, University of Naples Federico II, Piazzale Tecchio 80, Naples 80125, Italy.
  • Bevilacqua P; Center for Advanced Biomaterials for Health Care (CABHC), Fondazione Istituto Italiano di Tecnologia (IIT)CRIB, Largo Barsanti e Matteucci 53, Naples 80125, Italy.
  • Mollo V; Department of Chemical, Materials Engineering & Industrial Production, University of Naples Federico II, Piazzale Tecchio 80, Naples 80125, Italy.
  • Romano E; Center for Advanced Biomaterials for Health Care (CABHC), Fondazione Istituto Italiano di Tecnologia (IIT)CRIB, Largo Barsanti e Matteucci 53, Naples 80125, Italy.
  • Di Taranto MD; IRCCS SDN, via Gianturco 113, Naples, Italy.
  • Fortunato G; Center for Advanced Biomaterials for Health Care (CABHC), Fondazione Istituto Italiano di Tecnologia (IIT)CRIB, Largo Barsanti e Matteucci 53, Naples 80125, Italy.
  • Bracale UM; Department of Chemical, Materials Engineering & Industrial Production, University of Naples Federico II, Piazzale Tecchio 80, Naples 80125, Italy.
  • Tramontano L; Center for Advanced Biomaterials for Health Care (CABHC), Fondazione Istituto Italiano di Tecnologia (IIT)CRIB, Largo Barsanti e Matteucci 53, Naples 80125, Italy.
  • Diomaiuti TC; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, via S. Pansini 5, Naples 80131, Italy.
  • Torino E; CEINGE Advanced Biotechnologies S.C. A R.L., via Gaetano Salvatore 486, Naples 80145, Italy.
Contrast Media Mol Imaging ; 2021: 6664471, 2021.
Article em En | MEDLINE | ID: mdl-33880112
Despite the progress in cardiovascular research, atherosclerosis still represents the main cause of death worldwide. Clinically, the diagnosis of Atherosclerotic Cardiovascular Disease (ASCVD) relies on imaging methodologies including X-ray angiography and computed tomography (CT), which however still fails in the identification of patients at high risk of plaque rupture, the main cause of severe clinical events as stroke and heart attack. Magnetic resonance imaging, which is characterized by very high spatial resolution, could provide a better characterization of atherosclerotic plaque (AP) anatomy and composition, aiding in the identification of "vulnerable" plaques. In this context, hydrogel matrices, which have been demonstrated able to boost relaxometric properties of Gd-based contrast agents (CAs) by the effect of Hydrodenticity, represent a valuable tool towards the precision imaging of ASCVD improving the performance of this class of CAs while reducing systemic toxicity. In particular, hydrogel nanoparticles encapsulating Gd-DTPA can further contribute to providing CA-specific accumulation in the AP by nanoparticle surface decoration triggering an active targeting of the AP with the overall effect of allowing an earlier and more accurate diagnosis. In this work, we tested crosslinked Hyaluronic Acid Nanoparticles (cHANPs) in the complex environment of human atherosclerotic plaque. In addition, the surface of cHANPs was decorated with the antibody anti-CD36 (Ab36-cHANPs) for the active targeting of AP-associated macrophages. Results demonstrate that the Hydrodenticity of cHANPs and Ab36-cHANPs is preserved in this complex system and, preliminarily, that interaction of these probes with the AP is present.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article