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Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients.
Bateman, Nicholas W; Tarney, Christopher M; Abulez, Tamara; Soltis, Anthony R; Zhou, Ming; Conrads, Kelly; Litzi, Tracy; Oliver, Julie; Hood, Brian; Driggers, Paul; Viollet, Coralie; Dalgard, Clifton; Wilkerson, Matthew; Catherino, William; Hamilton, Chad A; Darcy, Kathleen M; Casablanca, Yovanni; Al-Hendy, Ayman; Segars, James; Conrads, Thomas P; Larry Maxwell, G.
Afiliação
  • Bateman NW; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Tarney CM; The John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Abulez T; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Soltis AR; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Zhou M; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Conrads K; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Litzi T; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Oliver J; The American Genome Center, Department of Anatomy, Physiology, and Genetics, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
  • Hood B; Women's Health Integrated Research Center, Women's Service Line, Inova Health System, 3300 Gallows Rd, Falls Church, VA, 22042, USA.
  • Driggers P; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Viollet C; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Dalgard C; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Wilkerson M; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Catherino W; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Hamilton CA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Darcy KM; Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.
  • Casablanca Y; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
  • Al-Hendy A; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Segars J; The American Genome Center, Department of Anatomy, Physiology, and Genetics, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
  • Conrads TP; The American Genome Center, Department of Anatomy, Physiology, and Genetics, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
  • Larry Maxwell G; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, 6720A Rockledge Dr., Suite 100, Bethesda, MD, 20817, USA.
Sci Rep ; 11(1): 9371, 2021 04 30.
Article em En | MEDLINE | ID: mdl-33931688
Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC (n = 16; FH-mutation confirmed) and non-syndromic (NS) patients (n = 12) identified a significantly higher protein:transcript correlation in HLRCC (R = 0.35) vs. NS ULMs (R = 0.242, MWU p = 0.0015). Co-altered proteins and transcripts (228) included antioxidant response element (ARE) target genes, such as thioredoxin reductase 1 (TXNRD1), and correlated with activation of NRF2-mediated oxidative stress response signaling in HLRCC ULMs. We confirm 185 transcripts previously described as altered between HLRCC and NS ULMs, 51 co-altered at the protein level and several elevated in HLRCC ULMs are involved in regulating cellular metabolism and glycolysis signaling. Furthermore, 367 S-(2-succino)cysteine peptides were identified in HLRCC ULMs, of which sixty were significantly elevated in HLRCC vs. NS ULMs (LogFC = 1.86, MWU p < 0.0001). These results confirm and define novel proteogenomic alterations in uterine leiomyoma tissues collected from HLRCC patients and underscore conserved molecular alterations correlating with inactivation of the FH tumor suppressor gene.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article