Ergosta-7,9(11),22-trien-3ß-ol Alleviates Intracerebral Hemorrhage-Induced Brain Injury and BV-2 Microglial Activation.

Hsueh, Po-Jen; Wang, Mong-Heng; Hsiao, Che-Jen; Chen, Chih-Kuang; Lin, Fan-Li; Huang, Shu-Hsien; Yen, Jing-Lun; Tsai, Ping-Huei; Kuo, Yueh-Hsiung; Hsiao, George

Hsueh, Po-Jen; Wang, Mong-Heng; Hsiao, Che-Jen; Chen, Chih-Kuang; Lin, Fan-Li; Huang, Shu-Hsien; Yen, Jing-Lun; Tsai, Ping-Huei; Kuo, Yueh-Hsiung; Hsiao, George.

Afiliação

Hsueh PJ; Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Wang MH; Department of Physiology, Medical College of Georgia, Augusta University, GA 30912, USA.
Hsiao CJ; Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chen CK; Laboratory of Neural Repair, Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
Lin FL; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Huang SH; Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Tayouan, Taoyuan 33378, Taiwan.
Yen JL; School of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Tsai PH; Menzies Institute for Medical Research, University of Tasmania, Hobart 7000, Tasmania, Australia.
Kuo YH; Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Hsiao G; Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

Molecules ; 26(10)2021 May 17.

Article em En | MEDLINE | ID: mdl-34067678

Assuntos

Lesões Encefálicas/tratamento farmacológico; Ergosterol/análogos & derivados; Ergosterol/farmacologia; Animais; Encéfalo/metabolismo; Lesões Encefálicas/metabolismo; Hemorragia Cerebral/tratamento farmacológico; Hemorragia Cerebral/metabolismo; Ciclo-Oxigenase 2/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/fisiologia; Ativação de Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Masculino; Metaloproteinase 9 da Matriz/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Microglia/efeitos dos fármacos; Polyporales/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

COX-2; JNK; MMP-9; ergosta-7,9(11),22-trien-3ß-ol; intracerebral hemorrhage; microglia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article