PSD-95 protects synapses from ß-amyloid.

Dore, Kim; Carrico, Zachary; Alfonso, Stephanie; Marino, Marc; Koymans, Karin; Kessels, Helmut W; Malinow, Roberto

Dore, Kim; Carrico, Zachary; Alfonso, Stephanie; Marino, Marc; Koymans, Karin; Kessels, Helmut W; Malinow, Roberto.

Afiliação

Dore K; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California, San Diego, San Diego, CA 92093, USA. Electronic address: kdore@health.ucsd.edu.
Carrico Z; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California, San Diego, San Diego, CA 92093, USA.
Alfonso S; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California, San Diego, San Diego, CA 92093, USA.
Marino M; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California, San Diego, San Diego, CA 92093, USA.
Koymans K; Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, the Netherlands.
Kessels HW; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California, San Diego, San Diego, CA 92093, USA; Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, the Netherlands.
Malinow R; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California, San Diego, San Diego, CA 92093, USA.

Cell Rep ; 35(9): 109194, 2021 06 01.

Article em En | MEDLINE | ID: mdl-34077732

Assuntos

Peptídeos beta-Amiloides/toxicidade; Proteína 4 Homóloga a Disks-Large/metabolismo; Neuroproteção; Sinapses/metabolismo; Animais; Espinhas Dendríticas/efeitos dos fármacos; Espinhas Dendríticas/metabolismo; Proteína 4 Homóloga a Disks-Large/antagonistas & inibidores; Transferência Ressonante de Energia de Fluorescência; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neuroproteção/efeitos dos fármacos; Ácido Palmítico/metabolismo; Fosfoproteínas Fosfatases/metabolismo; Domínios Proteicos; Ratos Sprague-Dawley; Receptores de N-Metil-D-Aspartato/química; Receptores de N-Metil-D-Aspartato/metabolismo; Sinapses/efeitos dos fármacos

Palavras-chave

ABHD17; Alzheimer's disease; FRET-FLIM; Fluorescence lifetime imaging; PSD-95 palmitoylation; Palmostatin B; Synapto-toxic signaling; ion-flux independent; neuroprotection; spine density

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article