Pharmacophore-based screening and modification of amiloride analogs for targeting the NhaP-type cation-proton antiporter in <i>Vibrio cholerae</i>.

Mourin, Muntahi; Bhattacharjee, Arittra; Wai, Alvan; Hausner, Georg; O'Neil, Joe; Dibrov, Pavel

Pharmacophore-based screening and modification of amiloride analogs for targeting the NhaP-type cation-proton antiporter in Vibrio cholerae.

Mourin, Muntahi; Bhattacharjee, Arittra; Wai, Alvan; Hausner, Georg; O'Neil, Joe; Dibrov, Pavel.

Afiliação

Mourin M; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Bhattacharjee A; Department of Biochemistry and Microbiology, North South University, Kuril - NSU Rd., Dhaka 1229, Bangladesh.
Wai A; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Hausner G; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
O'Neil J; Department of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Dibrov P; Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Can J Microbiol ; 67(11): 835-849, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34224663

Assuntos

Vibrio cholerae; Amilorida; Antiporters; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Cátions/metabolismo; Simulação de Acoplamento Molecular; Prótons; Trocadores de Sódio-Hidrogênio/genética; Vibrio cholerae/genética

Palavras-chave

NhaP2-type cation-proton antiporter; Vibrio cholerae; amiloride analogs; analogues de l'amiloride; antiport cation-proton de type NhaP2; inhibiteurs des antiports de type NhaP; inhibitors against NhaP-type antiporters

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google