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A triple-targeting delivery system carrying two anticancer agents.
Li, Hui; Lee, Chang-Hee; Shin, Injae.
Afiliação
  • Li H; Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea. injae@yonsei.ac.kr.
  • Lee CH; Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea. injae@yonsei.ac.kr.
  • Shin I; Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea. injae@yonsei.ac.kr.
Org Biomol Chem ; 19(37): 8009-8013, 2021 09 29.
Article em En | MEDLINE | ID: mdl-34236071
ABSTRACT
To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H2O2 and cathepsin B, which are normally present at high levels in tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article