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FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
Birsa, Nicol; Ule, Agnieszka M; Garone, Maria Giovanna; Tsang, Brian; Mattedi, Francesca; Chong, P Andrew; Humphrey, Jack; Jarvis, Seth; Pisiren, Melis; Wilkins, Oscar G; Nosella, Micheal L; Devoy, Anny; Bodo, Cristian; de la Fuente, Rafaela Fernandez; Fisher, Elizabeth M C; Rosa, Alessandro; Viero, Gabriella; Forman-Kay, Julie D; Schiavo, Giampietro; Fratta, Pietro.
Afiliação
  • Birsa N; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK. p.fratta@ucl.ac.uk n.birsa@ucl.ac.uk.
  • Ule AM; UK Dementia Research Institute, University College London, London WC1E 6BT, UK.
  • Garone MG; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Tsang B; Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Mattedi F; Center for Life Nano Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.
  • Chong PA; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
  • Humphrey J; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Jarvis S; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Pisiren M; Institute of Biophysics, CNR, Trento, Italy.
  • Wilkins OG; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
  • Nosella ML; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Devoy A; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Bodo C; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • de la Fuente RF; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Fisher EMC; The Francis Crick Institute, London NW1 1AT, UK.
  • Rosa A; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
  • Viero G; Maurice Wohl Clinical Neuroscience Institute, King's College London, London SE5 9RT, UK.
  • Forman-Kay JD; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Schiavo G; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Fratta P; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Sci Adv ; 7(30)2021 07.
Article em En | MEDLINE | ID: mdl-34290090
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article