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Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis.
Murphy, Thomas; Matheson, Justin; Mann, Robert E; Brands, Bruna; Wickens, Christine M; Tiwari, Arun K; Zai, Clement C; Kennedy, James; Le Foll, Bernard.
Afiliação
  • Murphy T; Centre for Addiction and Mental Health, Translational Addiction Research Laboratory, University of Toronto, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.
  • Matheson J; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Mann RE; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Brands B; Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, ON M6J 1H4, Canada.
  • Wickens CM; Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, ON M6J 1H4, Canada.
  • Tiwari AK; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Zai CC; Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, ON M6J 1H4, Canada.
  • Kennedy J; Controlled Substances and Cannabis Directorate, Health Canada, Ottawa, ON K1A 0K9, Canada.
  • Le Foll B; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Int J Mol Sci ; 22(14)2021 Jul 09.
Article em En | MEDLINE | ID: mdl-34299009
As many jurisdictions consider relaxing cannabis legislation and usage is increasing in North America and other parts of the world, there is a need to explore the possible genetic differences underlying the subjective effects of cannabis. This pilot study investigated specific genetic variations within the cannabinoid receptor 1 (CNR1) gene for association with the subjective effects of smoked cannabis. Data were obtained from a double-blinded, placebo-controlled clinical trial studying the impact of cannabis intoxication on driving performance. Participants randomized to the active cannabis group who consented to secondary genetic analysis (n = 52) were genotyped at the CNR1 rs1049353 and rs2023239 polymorphic areas. Maximum value and area under the curve (AUC) analyses were performed on subjective measures data. Analysis of subjective effects by genotype uncovered a global trend towards greater subjective effects for rs1049353 T-allele- and rs2023239 C-allele-carrying subjects. However, significant differences attributed to allelic identity were only documented for a subset of subjective effects. Our findings suggest that rs1049353 and rs2023239 minor allele carriers experience augmented subjective effects during acute cannabis intoxication.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article