PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.

Sun, Yilun; Chen, Jiji; Huang, Shar-Yin N; Su, Yijun P; Wang, Wenjie; Agama, Keli; Saha, Sourav; Jenkins, Lisa M; Pascal, John M; Pommier, Yves

Sun, Yilun; Chen, Jiji; Huang, Shar-Yin N; Su, Yijun P; Wang, Wenjie; Agama, Keli; Saha, Sourav; Jenkins, Lisa M; Pascal, John M; Pommier, Yves.

Afiliação

Sun Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. yilun.sun@nih.gov.
Chen J; Advanced Imaging and Microscopy Resource, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
Huang SN; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Su YP; Advanced Imaging and Microscopy Resource, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
Wang W; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Agama K; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Saha S; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Jenkins LM; Collaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada.
Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. pommier@nih.gov.

Nat Commun ; 12(1): 5010, 2021 08 18.

Article em En | MEDLINE | ID: mdl-34408146

Assuntos

DNA Topoisomerases Tipo I/metabolismo; DNA/genética; Complexo de Endopeptidases do Proteassoma/metabolismo; DNA/química; DNA/metabolismo; Dano ao DNA; Reparo do DNA; DNA Topoisomerases Tipo I/química; DNA Topoisomerases Tipo I/genética; Glicosídeo Hidrolases/genética; Glicosídeo Hidrolases/metabolismo; Células HEK293; Humanos; Poli ADP Ribosilação; Complexo de Endopeptidases do Proteassoma/química; Complexo de Endopeptidases do Proteassoma/genética; Proteólise; Ubiquitinação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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