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OPTICAL COHERENCE TOMOGRAPHY FEATURES OF POLYPOIDAL LESION CLOSURE IN POLYPOIDAL CHOROIDAL VASCULOPATHY TREATED WITH AFLIBERCEPT.
Tan, Anna C S; Jordan-Yu, Janice Marie; Vyas, Chinmayi Himanshuroy; Gan, Alfred Tau Liang; Teo, Kelvin Yi Chong; Chan, ChoI Mun; Mathur, Ranjana; Wong, Tien Yin; Chakravarthy, Usha; Cheung, Gemmy Chui Ming.
Afiliação
  • Tan ACS; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Jordan-Yu JM; Duke-NUS Medical School, Singapore, National University of Singapore, Singapore; and.
  • Vyas CH; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Gan ATL; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Teo KYC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Chan CM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Mathur R; Duke-NUS Medical School, Singapore, National University of Singapore, Singapore; and.
  • Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Chakravarthy U; Duke-NUS Medical School, Singapore, National University of Singapore, Singapore; and.
  • Cheung GCM; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Retina ; 42(1): 114-122, 2022 01 01.
Article em En | MEDLINE | ID: mdl-34412103
PURPOSE: To evaluate whether optical coherence tomography (OCT) can determine polypoidal lesion (PL) perfusion in polypoidal choroidal vasculopathy eyes after 12 months of aflibercept monotherapy. Polypoidal lesion perfusion status, assessed by indocyanine green angiography, is an important anatomical outcome in polypoidal choroidal vasculopathy management. METHODS: Post hoc data from a prospective randomized, open-label, study in eyes with polypoidal choroidal vasculopathy undergoing monotherapy with aflibercept evaluated PL perfusion status based on indocyanine green angiography (gold standard) and OCT features from baseline to 12 months. RESULTS: Individual PLs (110 in total) from 48 eyes (48 patients) showed at 12 months; 57/110 PLs (51.8%) were closed on indocyanine green angiography. At 12 months, eyes with closed PLs were more likely to have the following OCT features: 1) no subretinal fluid (67.1% vs. 32.9%), 2) smaller pigment epithelial detachment height (67.2 [±43.8] vs. 189.2 [±104.9] µm), 3) densely hyperreflective pigment epithelial detachment contents (84.0% vs. 16.0%), 4) an absence of a hyperreflective ring(64.0% vs. 36.0%), and a 5) indistinct overlying retinal pigment epithelial (71.4% vs. 28.6%) (all P < 0.05). The three highest performing OCT features that differentiated perfused from closed PLs were (1), (3), and (4) (area under the receiver operating characteristic curve 0.85, 0.73, and 0.70, respectively). A combination of these three features achieved an area under the receiver operating characteristic curve of 0.90. CONCLUSION: Polypoidal lesion closure, an important anatomical treatment outcome in polypoidal choroidal vasculopathy typically defined by indocyanine green angiography, can be accurately detected by specific OCT features.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article