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Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis.
de Moura, Francyelle Borges Rosa; Ferreira, Bruno Antonio; Deconte, Simone Ramos; Landim, Breno Costa; Justino, Allisson Benatti; Aro, Andrea Aparecida de; Espindola, Foued Salmen; Rodrigues, Rodney Alexandre Ferreira; Ribeiro, Daniele Lisboa; Araújo, Fernanda de Assis; Tomiosso, Tatiana Carla.
Afiliação
  • de Moura FBR; Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, zip code 38400-902, Uberlândia, MG, Brazil.
  • Ferreira BA; Institute of Biology, State University of Campinas, Street Monteiro Lobato, 255, zip code 13083-862, Campinas, SP, Brazil.
  • Deconte SR; Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, zip code 38400-902, Uberlândia, MG, Brazil.
  • Landim BC; Institute of Biotechnology, Federal University of Uberlândia, Street Acre 1004, zip code 38405-319, Uberlândia, MG, Brazil.
  • Justino AB; Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, zip code 38400-902, Uberlândia, MG, Brazil.
  • Aro AA; Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, zip code 38400-902, Uberlândia, MG, Brazil.
  • Espindola FS; Institute of Biotechnology, Federal University of Uberlândia, Street Acre 1004, zip code 38405-319, Uberlândia, MG, Brazil.
  • Rodrigues RAF; Institute of Biology, State University of Campinas, Street Monteiro Lobato, 255, zip code 13083-862, Campinas, SP, Brazil.
  • Ribeiro DL; Institute of Biotechnology, Federal University of Uberlândia, Street Acre 1004, zip code 38405-319, Uberlândia, MG, Brazil.
  • Araújo FA; Multidisciplinary Center of Chemical, Biological and Agricultural Research, State University of Campinas, Street Alexandre Cazelatto 999, zip code 13148-218, Paulínia, SP, Brazil.
  • Tomiosso TC; Institute of Biomedical Sciences, Federal University of Uberlândia, Avenue Pará 1720, zip code 38400-902, Uberlândia, MG, Brazil.
J Tradit Complement Med ; 11(5): 446-456, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34522639
ABSTRACT
BACKGROUND AND

AIM:

Maytenus ilicifolia has analgesic, healing, antioxidant and anti-inflammatory properties. This study evaluated effect of the hydroalcoholic extract of M. ilicifolia leaves on skin wound repair. EXPERIMENTAL PROCEDURE Wounds were induced on mice and treated with the extract. The treatment was performed daily, until day 7 after wound induction. Wound closure was measured and the features of the repaired tissue were investigated, including mast cell quantification, neutrophil and macrophage activities, collagen deposition, angiogenesis, and pro-metalloproteases and metalloproteases 2 and 9 activity (pro-MMPs and MMPs). RESULTS AND

CONCLUSION:

The M. ilicifolia extract accelerated the closure of wounds. The extract at a concentration of 4% was found to be effective, presenting anti-inflammatory effects and hemoglobin increased, along with increased soluble, total and type III collagens in the wound. In addition, there was an increase in pro-MMP9 and MMP9 activity after day 7th of treatment. The phenolic compounds and tannins present in this plant could be associated with the anti-inflammatory and healing activities observed in this study. Therefore, the ability to modulate essential parameters for accelerated and adequate healing as shown here suggests that the use of standardised extracts of M. ilicifolia and its fractions enriched in polyphenols may represent a therapeutic strategy for the treatment of wounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article