GALNT14 regulates ferroptosis and apoptosis of ovarian cancer through the EGFR/mTOR pathway.
Future Oncol
; 18(2): 149-161, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-34643088
ABSTRACT
Background:
Chemoresistance usually occurs in ovarian cancer. We aimed to explore the mechanisms of chemoresistance.Methods:
Western blotting assay was used to detect the expression of GALNT14. Further cell function experiments were performed to investigate the effect of GALNT14 in ovarian cancer.Results:
GALNT14 is significantly upregulated in ovarian cancer. Downregulation of GALNT14 significantly inhibits both apoptosis and ferroptosis of ovarian cancer cells. A further mechanism assay illustrated that downregulation of GALNT14 suppresses the activity of the mTOR pathway through modifying O-glycosylation of EGFR. Finally, an additive effect promoting cell death occurs with a combination of an mTOR inhibitor and cisplatin.Conclusion:
Our study might provide a promising method to overcome cisplatin resistance for patients with ovarian cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article