Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.

Khatun, Mousumi; Kumar, Krishna; Baidya, Ayana; Mondal, Rajiv Kumar; Baszczynski, Ondrej; Kalcic, Filip; Banerjee, Soma; Dhali, Gopal Krishna; Das, Kausik; Chowdhury, Abhijit; Janeba, Zlatko; Chakrabarti, Saikat; Datta, Simanti

Khatun, Mousumi; Kumar, Krishna; Baidya, Ayana; Mondal, Rajiv Kumar; Baszczynski, Ondrej; Kalcic, Filip; Banerjee, Soma; Dhali, Gopal Krishna; Das, Kausik; Chowdhury, Abhijit; Janeba, Zlatko; Chakrabarti, Saikat; Datta, Simanti.

Afiliação

Khatun M; Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Kumar K; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Baidya A; Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Mondal RK; Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Baszczynski O; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Kalcic F; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Banerjee S; Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Dhali GK; Department of Gastroenterology, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Das K; Department of Hepatology, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Chowdhury A; Department of Hepatology, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Janeba Z; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Chakrabarti S; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Datta S; Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.

J Virol ; 96(2): e0180021, 2022 01 26.

Article em En | MEDLINE | ID: mdl-34730399

Assuntos

Antivirais/farmacologia; Desenho de Fármacos; Vírus da Hepatite B/efeitos dos fármacos; Hepatite B Crônica/tratamento farmacológico; Inibidores da Transcriptase Reversa/farmacologia; Antivirais/química; Antivirais/uso terapêutico; Farmacorresistência Viral/efeitos dos fármacos; Farmacorresistência Viral/genética; Genótipo; Guanina/análogos & derivados; Guanina/química; Guanina/farmacologia; Guanina/uso terapêutico; Vírus da Hepatite B/enzimologia; Vírus da Hepatite B/genética; Hepatite B Crônica/virologia; Humanos; Mutação; Organofosfonatos/química; Organofosfonatos/farmacologia; Pró-Fármacos; Domínios Proteicos; DNA Polimerase Dirigida por RNA/química; DNA Polimerase Dirigida por RNA/genética; Inibidores da Transcriptase Reversa/química; Inibidores da Transcriptase Reversa/uso terapêutico; Tenofovir/química; Tenofovir/farmacologia; Tenofovir/uso terapêutico; Carga Viral/efeitos dos fármacos

Palavras-chave

antiviral activity; entecavir; hepatitis B virus D-subgenotypes; high throughput virtual screening; phosphonate prodrug; tenofovir

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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