A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells.

Basu, Abhijit; Penumutchu, Srinivasa; Nguyen, Kien; Mbonye, Uri; Tolbert, Blanton S; Karn, Jonathan; Komar, Anton A; Mazumder, Barsanjit

Basu, Abhijit; Penumutchu, Srinivasa; Nguyen, Kien; Mbonye, Uri; Tolbert, Blanton S; Karn, Jonathan; Komar, Anton A; Mazumder, Barsanjit.

Afiliação

Basu A; Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State Universitygrid.254298.0, Cleveland, Ohio, USA.
Penumutchu S; Department of Chemistry, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Nguyen K; Department of Molecular Biology and Microbiology, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Mbonye U; Department of Molecular Biology and Microbiology, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Tolbert BS; Department of Chemistry, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.
Komar AA; Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State Universitygrid.254298.0, Cleveland, Ohio, USA.
Mazumder B; Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State Universitygrid.254298.0, Cleveland, Ohio, USA.

J Virol ; 96(2): e0167821, 2022 01 26.

Article em En | MEDLINE | ID: mdl-34757848

Assuntos

COVID-19; Interações entre Hospedeiro e Microrganismos; RNA Viral/imunologia; SARS-CoV-2; Células A549; COVID-19/imunologia; COVID-19/virologia; Interações entre Hospedeiro e Microrganismos/genética; Interações entre Hospedeiro e Microrganismos/imunologia; Humanos; Ligação Proteica; SARS-CoV-2/genética; SARS-CoV-2/imunologia; Internalização do Vírus

Palavras-chave

RNA virus; cell signaling; ribosomal loading; ribosomal proteins; translational control; viral RNA element; virus-host interactions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article