miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy.

Tsitkanou, Stavroula; Della Gatta, Paul A; Abbott, Gavin; Wallace, Marita A; Lindsay, Angus; Gerlinger-Romero, Frederico; Walker, Adam K; Foletta, Victoria C; Russell, Aaron P

Tsitkanou, Stavroula; Della Gatta, Paul A; Abbott, Gavin; Wallace, Marita A; Lindsay, Angus; Gerlinger-Romero, Frederico; Walker, Adam K; Foletta, Victoria C; Russell, Aaron P.

Afiliação

Tsitkanou S; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Della Gatta PA; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Abbott G; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Wallace MA; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Lindsay A; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Gerlinger-Romero F; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Walker AK; Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia; Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, NSW, Australia.
Foletta VC; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Russell AP; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia. Electronic address: aaron.russell@deakin.edu.au.

Neurobiol Dis ; 162: 105559, 2022 01.

Article em En | MEDLINE | ID: mdl-34774794

Assuntos

Esclerose Lateral Amiotrófica; Proteínas de Ligação a DNA; MicroRNAs; Proteinopatias TDP-43; Esclerose Lateral Amiotrófica/metabolismo; Animais; Proteínas de Ligação a DNA/genética; Modelos Animais de Doenças; Humanos; Camundongos; Camundongos Transgênicos; MicroRNAs/genética; Proteinopatias TDP-43/genética

Palavras-chave

Amyotrophic lateral sclerosis; Motor neuron disease; Myogenic regulatory factors; Skeletal muscle; TDP-43; miR-23a; rNLS8 mice; ß-Amyloid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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