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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Dilworth, David; Hanley, Ronan P; Ferreira de Freitas, Renato; Allali-Hassani, Abdellah; Zhou, Mengqi; Mehta, Naimee; Marunde, Matthew R; Ackloo, Suzanne; Carvalho Machado, Raquel Arminda; Khalili Yazdi, Aliakbar; Owens, Dominic D G; Vu, Victoria; Nie, David Y; Alqazzaz, Mona; Marcon, Edyta; Li, Fengling; Chau, Irene; Bolotokova, Albina; Qin, Su; Lei, Ming; Liu, Yanli; Szewczyk, Magdalena M; Dong, Aiping; Kazemzadeh, Sina; Abramyan, Tigran; Popova, Irina K; Hall, Nathan W; Meiners, Matthew J; Cheek, Marcus A; Gibson, Elisa; Kireev, Dmitri; Greenblatt, Jack F; Keogh, Michael-C; Min, Jinrong; Brown, Peter J; Vedadi, Masoud; Arrowsmith, Cheryl H; Barsyte-Lovejoy, Dalia; James, Lindsey I; Schapira, Matthieu.
Afiliação
  • Dilworth D; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada. david.dilworth@utoronto.ca.
  • Hanley RP; BlueRock Therapeutics, Toronto, Ontario, Canada. david.dilworth@utoronto.ca.
  • Ferreira de Freitas R; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Allali-Hassani A; C4 Therapeutics, Watertown, MA, USA.
  • Zhou M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Mehta N; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Rua Arcturus 3, São Bernardo do Campo, Brazil.
  • Marunde MR; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Ackloo S; Incyte, Wilmington, DE, USA.
  • Carvalho Machado RA; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Khalili Yazdi A; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China.
  • Owens DDG; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Vu V; Nurix Therapeutics, San Francisco, CA, USA.
  • Nie DY; EpiCypher Inc., Durham, NC, USA.
  • Alqazzaz M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Marcon E; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Chau I; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Bolotokova A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Qin S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Lei M; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Liu Y; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Szewczyk MM; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Dong A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Kazemzadeh S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Abramyan T; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Popova IK; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Hall NW; Life Science Research Center, Southern University of Science and Technology, Shenzhen, China.
  • Meiners MJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Cheek MA; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China.
  • Gibson E; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Kireev D; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
  • Greenblatt JF; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Keogh MC; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
  • Min J; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Brown PJ; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Vedadi M; Atomwise, San Francisco, CA, USA.
  • Arrowsmith CH; EpiCypher Inc., Durham, NC, USA.
  • Barsyte-Lovejoy D; EpiCypher Inc., Durham, NC, USA.
  • James LI; EpiCypher Inc., Durham, NC, USA.
  • Schapira M; EpiCypher Inc., Durham, NC, USA.
Nat Chem Biol ; 18(1): 56-63, 2022 01.
Article em En | MEDLINE | ID: mdl-34782742
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article