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Association of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population.
Said, Rahma; Jenni, Rim; Boussetta, Sami; Ammous, Feryel; Zouari, Skander; Zaghbib, Selim; Chakroun, Marouene; Derouiche, Amine; Chebil, Mohamed; Ouerhani, Slah.
Afiliação
  • Said R; Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.
  • Jenni R; Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.
  • Boussetta S; Laboratory of Genetics, Immunology, and Human Pathology, Faculty of Sciences of Tunis.
  • Ammous F; Laboratory of Genetics, Immunology, and Human Pathology, Faculty of Sciences of Tunis.
  • Zouari S; Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.
  • Zaghbib S; Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.
  • Chakroun M; Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.
  • Derouiche A; Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.
  • Chebil M; Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.
  • Ouerhani S; Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.
J Clin Lab Anal ; 36(1): e24129, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34799866
BACKGROUND: Angiotensin-converting enzyme (ACE) plays a pivotal role in several pathologies including cancers. The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. We aimed to investigate for the first time, to our Knowledge, in North Africa the potential relationship between ACE I/D polymorphism with PC susceptibility and clinical outcomes of PC patients. METHODS: This case-control study included 143 healthy individuals and 124 patients diagnosed with PC. Using genomic DNA, the samples were genotyped for ACE I/D polymorphism by polymerase chain reaction (PCR). RESULTS: We found that The D allele is significantly associated with an increased risk of PC and D/D + D/I genotypes were at 3 times increased risk of PC ([p = 0.005], OR = 2.95, IC 95% = 1.26-7.09) compared with I/I genotype (p = 0.003, OR = 0.3, IC 95% = 0.12-0.74). We observed an association between D/D and D/I genotypes with advanced age (≥70 years) (p = 0.014; r2  = 0.22). Furthermore, there is a significant prediction of advanced Gleason score ≥8 based on epidemiological parameters and ACE genotype (p = 0.000; R2  = 0.349), although no significant association was observed with stage and metastasis. CONCLUSION: The ACE I/D polymorphism is likely to predispose to PC and could play a role in PC progression and aggressiveness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Ano de publicação: 2022 Tipo de documento: Article