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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Brown, Alastair J H; Bradley, Sophie J; Marshall, Fiona H; Brown, Giles A; Bennett, Kirstie A; Brown, Jason; Cansfield, Julie E; Cross, David M; de Graaf, Chris; Hudson, Brian D; Dwomoh, Louis; Dias, João M; Errey, James C; Hurrell, Edward; Liptrot, Jan; Mattedi, Giulio; Molloy, Colin; Nathan, Pradeep J; Okrasa, Krzysztof; Osborne, Greg; Patel, Jayesh C; Pickworth, Mark; Robertson, Nathan; Shahabi, Shahram; Bundgaard, Christoffer; Phillips, Keith; Broad, Lisa M; Goonawardena, Anushka V; Morairty, Stephen R; Browning, Michael; Perini, Francesca; Dawson, Gerard R; Deakin, John F W; Smith, Robert T; Sexton, Patrick M; Warneck, Julie; Vinson, Mary; Tasker, Tim; Tehan, Benjamin G; Teobald, Barry; Christopoulos, Arthur; Langmead, Christopher J; Jazayeri, Ali; Cooke, Robert M; Rucktooa, Prakash; Congreve, Miles S; Weir, Malcolm; Tobin, Andrew B.
Afiliação
  • Brown AJH; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Bradley SJ; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Marshall FH; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Brown GA; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Bennett KA; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Brown J; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Cansfield JE; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Cross DM; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Cross Pharma Consulting Ltd, 20-22 Wenlock Road, London, N17GU, UK.
  • de Graaf C; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Hudson BD; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Dwomoh L; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Dias JM; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Errey JC; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Hurrell E; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Liptrot J; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Mattedi G; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Molloy C; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Nathan PJ; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Herchel Smith Building, Cambridge, CB20SZ, UK.
  • Okrasa K; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Osborne G; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Patel JC; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Pickworth M; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Robertson N; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Shahabi S; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK.
  • Bundgaard C; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK; H. Lundbeck A/S, Neuroscience Research, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.
  • Phillips K; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK.
  • Broad LM; Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK.
  • Goonawardena AV; Center for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
  • Morairty SR; Center for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
  • Browning M; University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX12JD, UK; P1vital, Manor house, Howbery Buisness Park, Wallingford, OX108BA, UK.
  • Perini F; Centre for Cognitive Neuroscience - Duke-NUS Medical School, 8 College Road, 169857, Singapore.
  • Dawson GR; University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX12JD, UK.
  • Deakin JFW; Neuroscience and Psychiatry Unit, University of Manchester, Manchester, M139PT UK.
  • Smith RT; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Vi
  • Warneck J; Protogenia Consulting Ltd, PO-Box 289, Ely, CB79DR, UK.
  • Vinson M; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Tasker T; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Tehan BG; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Teobald B; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia.
  • Langmead CJ; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia.
  • Jazayeri A; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Cooke RM; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Rucktooa P; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Congreve MS; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
  • Weir M; Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK. Electronic address: malcolm.weir@soseiheptares.com.
  • Tobin AB; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK. Electronic address: andrew.tobin@glasgow.ac.uk.
Cell ; 184(24): 5886-5901.e22, 2021 11 24.
Article em En | MEDLINE | ID: mdl-34822784
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Limite: Aged80 Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Limite: Aged80 Idioma: En Ano de publicação: 2021 Tipo de documento: Article