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Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.
Meng, Wei; Pi, Zulan; Brigance, Robert; Rossi, Karen A; Schumacher, William A; Bostwick, Jeffrey S; Gargalovic, Peter S; Onorato, Joelle M; Luk, Chiuwa E; Generaux, Claudia N; Wang, Tao; Wexler, Ruth R; Finlay, Heather J.
Afiliação
  • Meng W; Departments of Discovery Chemistry, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Pi Z; Departments of Discovery Chemistry, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Brigance R; Departments of Discovery Chemistry, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Rossi KA; Computer-Assisted Drug Design, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Schumacher WA; Cardiovascular Drug Discovery Biology, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Bostwick JS; Cardiovascular Drug Discovery Biology, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Gargalovic PS; Cardiovascular Drug Discovery Biology, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Onorato JM; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Luk CE; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Generaux CN; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Wang T; Leads Discovery and Optimization, Research and Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Wexler RR; Departments of Discovery Chemistry, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Finlay HJ; Departments of Discovery Chemistry, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
J Med Chem ; 64(24): 18102-18113, 2021 12 23.
Article em En | MEDLINE | ID: mdl-34855405
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article