Adamantane-Substituted Purines and Their ß-Cyclodextrin Complexes: Synthesis and Biological Activity.

Rouchal, Michal; Rudolfová, Jana; Krystof, Vladimír; Vojácková, Veronika; Cmelík, Richard; Vícha, Robert

Rouchal, Michal; Rudolfová, Jana; Krystof, Vladimír; Vojácková, Veronika; Cmelík, Richard; Vícha, Robert.

Afiliação

Rouchal M; Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 760 01 Zlín, Czech Republic.
Rudolfová J; Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 760 01 Zlín, Czech Republic.
Krystof V; Department of Experimental Biology, Palacký University, Slechtitelu 27, 783 71 Olomouc, Czech Republic.
Vojácková V; Department of Experimental Biology, Palacký University, Slechtitelu 27, 783 71 Olomouc, Czech Republic.
Cmelík R; Institute of Analytical Chemistry of the Czech Academy of Sciences, Veverí 97, 602 00 Brno, Czech Republic.
Vícha R; Department of Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 760 01 Zlín, Czech Republic.

Int J Mol Sci ; 22(23)2021 Nov 24.

Article em En | MEDLINE | ID: mdl-34884480

Assuntos

Adamantano/química; Antineoplásicos/farmacologia; Quinase 2 Dependente de Ciclina/antagonistas & inibidores; Inibidores de Proteínas Quinases/farmacologia; Purinas/química; beta-Ciclodextrinas/química; Antineoplásicos/química; Humanos; Células K562; Células MCF-7; Relação Estrutura-Atividade

Palavras-chave

2,6,9-trisubstituted purine; adamantane; cyclin-dependent kinase; cytotoxicity; molecular docking; ß-cyclodextrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article