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AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset.
Goertsen, David; Flytzanis, Nicholas C; Goeden, Nick; Chuapoco, Miguel R; Cummins, Alexander; Chen, Yijing; Fan, Yingying; Zhang, Qiangge; Sharma, Jitendra; Duan, Yangyang; Wang, Liping; Feng, Guoping; Chen, Yu; Ip, Nancy Y; Pickel, James; Gradinaru, Viviana.
Afiliação
  • Goertsen D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Flytzanis NC; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Goeden N; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Chuapoco MR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Cummins A; National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Chen Y; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute
  • Fan Y; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute
  • Zhang Q; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sharma J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Duan Y; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wang L; Picower Institute of Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Feng G; Tan & Yang Center for Autism Research, McGovern Institute of Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Chen Y; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Ip NY; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Pickel J; Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute
  • Gradinaru V; McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Neurosci ; 25(1): 106-115, 2022 01.
Article em En | MEDLINE | ID: mdl-34887588

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article