Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.

Yang, Yun; Tapias, Victor; Acosta, Diana; Xu, Hui; Chen, Huanlian; Bhawal, Ruchika; Anderson, Elizabeth T; Ivanova, Elena; Lin, Hening; Sagdullaev, Botir T; Chen, Jianer; Klein, William L; Viola, Kirsten L; Gandy, Sam; Haroutunian, Vahram; Beal, M Flint; Eliezer, David; Zhang, Sheng; Gibson, Gary E

Yang, Yun; Tapias, Victor; Acosta, Diana; Xu, Hui; Chen, Huanlian; Bhawal, Ruchika; Anderson, Elizabeth T; Ivanova, Elena; Lin, Hening; Sagdullaev, Botir T; Chen, Jianer; Klein, William L; Viola, Kirsten L; Gandy, Sam; Haroutunian, Vahram; Beal, M Flint; Eliezer, David; Zhang, Sheng; Gibson, Gary E.

Afiliação

Yang Y; Integrated Medicine Research Center for Neurological Rehabilitation, College of Medicine, Jiaxing University, 314001, Jiaxing, China.
Tapias V; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Acosta D; Burke Neurological Institute, White Plains, NY, 10605, USA.
Xu H; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Chen H; Department of Biochemistry, Weill Cornell Medicine, New York, NY, 10065, USA.
Bhawal R; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Anderson ET; Burke Neurological Institute, White Plains, NY, 10605, USA.
Ivanova E; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Lin H; Burke Neurological Institute, White Plains, NY, 10605, USA.
Sagdullaev BT; Proteomics and Metabolomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.
Chen J; Proteomics and Metabolomics Facility, Institute of Biotechnology, Cornell University, Ithaca, NY, 14853, USA.
Klein WL; Imaging Core, Burke Neurological Institute, White Plains, NY, 10605, USA.
Viola KL; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 10591, USA.
Gandy S; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Haroutunian V; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Beal MF; Ophthalmology and Neuroscience, Weill Cornell Medicine, New York, NY, 10065, USA.
Eliezer D; Laboratory for Visual Plasticity and Repair, Burke Neurological Institute, White Plains, NY, 10605, USA.
Zhang S; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 10591, USA.
Gibson GE; Integrated Medicine Research Center for Neurological Rehabilitation, College of Medicine, Jiaxing University, 314001, Jiaxing, China.

Nat Commun ; 13(1): 159, 2022 01 10.

Article em En | MEDLINE | ID: mdl-35013160

Assuntos

Doença de Alzheimer/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Placa Amiloide/metabolismo; Processamento de Proteína Pós-Traducional; Ácido Succínico/metabolismo; Proteínas tau/metabolismo; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Sequência de Aminoácidos; Precursor de Proteína beta-Amiloide/genética; Animais; Autopsia; Encéfalo/metabolismo; Encéfalo/patologia; Estudos de Casos e Controles; Modelos Animais de Doenças; Perfilação da Expressão Gênica; Humanos; Camundongos; Camundongos Transgênicos; Mitocôndrias/genética; Mitocôndrias/metabolismo; Mitocôndrias/patologia; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Placa Amiloide/genética; Placa Amiloide/patologia; Agregados Proteicos; Proteólise; Proteoma/genética; Proteoma/metabolismo; Proteínas tau/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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