Extended Prophylactic Effect of N-tert-Butyl-&#945;-phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta.

Sobocan, Nikola; Himelreich-Peric, Marta; Katusic-Bojanac, Ana; Krasic, Jure; Sincic, Nino; Majic, Zeljka; Juric-Lekic, Gordana; Serman, Ljiljana; Maric, Andreja; Jezek, Davor; Bulic-Jakus, Floriana

Extended Prophylactic Effect of N-tert-Butyl-α-phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta.

Sobocan, Nikola; Himelreich-Peric, Marta; Katusic-Bojanac, Ana; Krasic, Jure; Sincic, Nino; Majic, Zeljka; Juric-Lekic, Gordana; Serman, Ljiljana; Maric, Andreja; Jezek, Davor; Bulic-Jakus, Floriana.

Afiliação

Sobocan N; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Himelreich-Peric M; Department of Gastroenterology, University Hospital Merkur, 10000 Zagreb, Croatia.
Katusic-Bojanac A; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Krasic J; Department of Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Sincic N; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Majic Z; Department of Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Juric-Lekic G; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Serman L; Department of Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Maric A; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Jezek D; Department of Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Bulic-Jakus F; Department of Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Int J Mol Sci ; 23(2)2022 Jan 06.

Article em En | MEDLINE | ID: mdl-35054786

Assuntos

Azacitidina/toxicidade; Óxidos N-Cíclicos/farmacologia; Metilação de DNA/efeitos dos fármacos; Estresse Oxidativo; Placenta/patologia; 8-Hidroxi-2'-Desoxiguanosina/metabolismo; Animais; Biomarcadores/metabolismo; Proliferação de Células/efeitos dos fármacos; Feminino; Nitrosação/efeitos dos fármacos; Tamanho do Órgão/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Placenta/efeitos dos fármacos; Gravidez; Antígeno Nuclear de Célula em Proliferação/metabolismo; Ratos Endogâmicos F344; Tirosina/análogos & derivados; Tirosina/metabolismo

Palavras-chave

5-azacytidine; N-tert-Butyl-α-phenylnitron; PBN; nitrotyrosine; oxidative stress; oxoguanosine; placenta

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article