Improved Core Viscosity Achieved by PDLLA10kCo-Incorporation Promoted Drug Loading and Stability of mPEG2k-b-PDLLA2.4k Micelles.

Guo, Chen; Zhang, Ying; Yuan, Haoyang; Zhang, Yu; Yin, Tian; He, Haibing; Gou, Jingxin; Tang, Xing

Improved Core Viscosity Achieved by PDLLA_10kCo-Incorporation Promoted Drug Loading and Stability of mPEG_2k-b-PDLLA_2.4k Micelles.

Guo, Chen; Zhang, Ying; Yuan, Haoyang; Zhang, Yu; Yin, Tian; He, Haibing; Gou, Jingxin; Tang, Xing.

Afiliação

Guo C; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
Zhang Y; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
Yuan H; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
Zhang Y; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
Yin T; School of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
He H; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China.
Gou J; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China. jxgou_syphu@163.com.
Tang X; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, People's Republic of China. tanglab@126.com.

Pharm Res ; 39(2): 369-379, 2022 Feb.

Article em En | MEDLINE | ID: mdl-35118566

Assuntos

Antineoplásicos Fitogênicos/química; Portadores de Fármacos; Paclitaxel/química; Poliésteres/química; Polietilenoglicóis/química; 2-Hidroxipropil-beta-Ciclodextrina/química; Animais; Antineoplásicos Fitogênicos/administração & dosagem; Antineoplásicos Fitogênicos/farmacocinética; Composição de Medicamentos; Liberação Controlada de Fármacos; Liofilização; Injeções Intravenosas; Micelas; Paclitaxel/administração & dosagem; Paclitaxel/farmacocinética; Tamanho da Partícula; Ratos Sprague-Dawley; Viscosidade

Palavras-chave

Lyophilization protectant; Micelles; drug loading; dynamic stability

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article