Novel potent benzimidazole-based microsomal prostaglandin E<sub>2</sub> synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C<sub>4</sub> synthase.

Ergül, Azize Gizem; Maz, Tugçe Gür; Kretzer, Christian; Olgaç, Abdurrahman; Jordan, Paul M; Çaliskan, Burcu; Werz, Oliver; Banoglu, Erden

Novel potent benzimidazole-based microsomal prostaglandin E₂ synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C₄ synthase.

Ergül, Azize Gizem; Maz, Tugçe Gür; Kretzer, Christian; Olgaç, Abdurrahman; Jordan, Paul M; Çaliskan, Burcu; Werz, Oliver; Banoglu, Erden.

Afiliação

Ergül AG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Maz TG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Kretzer C; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743, Jena, Germany.
Olgaç A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Jordan PM; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743, Jena, Germany.
Çaliskan B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743, Jena, Germany.
Banoglu E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey. Electronic address: banoglu@gazi.edu.tr.

Eur J Med Chem ; 231: 114167, 2022 Mar 05.

Article em En | MEDLINE | ID: mdl-35152061

Assuntos

Leucotrieno C4; Microssomos; Anti-Inflamatórios/farmacologia; Benzimidazóis/farmacologia; Dinoprostona; Humanos; Prostaglandina-E Sintases

Palavras-chave

Benzimidazole; Benzyloxy; Leukotriene; Oxadiazolethione; PGE(2); mPGES-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article