Interplay between nuclear factor-&#954;B, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells.

Bansal, Akanksha; Mostafa, Mahmoud M; Kooi, Cora; Sasse, Sarah K; Michi, Aubrey N; Shah, Suharsh V; Leigh, Richard; Gerber, Anthony N; Newton, Robert

Interplay between nuclear factor-κB, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells.

Bansal, Akanksha; Mostafa, Mahmoud M; Kooi, Cora; Sasse, Sarah K; Michi, Aubrey N; Shah, Suharsh V; Leigh, Richard; Gerber, Anthony N; Newton, Robert.

Afiliação

Bansal A; Department of Physiology & Pharmacology and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Mostafa MM; Department of Physiology & Pharmacology and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Kooi C; Department of Medicine and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Sasse SK; Department of Medicine, National Jewish Health, Denver, Colorado, USA.
Michi AN; Department of Physiology & Pharmacology and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Shah SV; Department of Physiology & Pharmacology and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Leigh R; Department of Physiology & Pharmacology and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medicine and Airways Inflammation Research Group, Snyder Institute for Chronic Diseas
Gerber AN; Department of Medicine, National Jewish Health, Denver, Colorado, USA; Department of Medicine, University of Colorado, Aurora, Colorado, USA.
Newton R; Department of Physiology & Pharmacology and Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: rnewton@ucalgary.ca.

J Biol Chem ; 298(4): 101747, 2022 04.

Article em En | MEDLINE | ID: mdl-35189144

Assuntos

Asma; NF-kappa B; Receptores de Glucocorticoides; Receptor 2 Toll-Like; Proteínas Quinases p38 Ativadas por Mitógeno; Asma/fisiopatologia; Budesonida/farmacologia; Citocinas/metabolismo; Dexametasona/farmacologia; Células Epiteliais/metabolismo; Regulação da Expressão Gênica/efeitos dos fármacos; Glucocorticoides/farmacologia; Humanos; Pulmão/citologia; Pulmão/metabolismo; NF-kappa B/metabolismo; Receptores de Glucocorticoides/metabolismo; Receptor 2 Toll-Like/genética; Receptor 2 Toll-Like/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

NF-κB; airway inflammation; cell signaling; chromatin immunoprecipitation; gene transcription; glucocorticoid receptor; p38 MAPK; toll-like receptor 2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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