DCZ0415, a small-molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/ß-catenin pathway in colorectal cancer.

Agarwal, Sumit; Afaq, Farrukh; Bajpai, Prachi; Kim, Hyung-Gyoon; Elkholy, Amr; Behring, Michael; Chandrashekar, Darshan Shimoga; Diffalha, Sameer Al; Khushman, Moh'd; Sugandha, Shajan P; Varambally, Sooryanarayana; Manne, Upender

Agarwal, Sumit; Afaq, Farrukh; Bajpai, Prachi; Kim, Hyung-Gyoon; Elkholy, Amr; Behring, Michael; Chandrashekar, Darshan Shimoga; Diffalha, Sameer Al; Khushman, Moh'd; Sugandha, Shajan P; Varambally, Sooryanarayana; Manne, Upender.

Afiliação

Agarwal S; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Afaq F; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Bajpai P; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Kim HG; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Elkholy A; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Behring M; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Chandrashekar DS; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Diffalha SA; Department of Pathology, University of Alabama at Birmingham, AL, USA.
Khushman M; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, AL, USA.
Sugandha SP; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, AL, USA.
Varambally S; Department of Medicine, Division of Medical Oncology, University of Alabama at Birmingham, AL, USA.
Manne U; Department of Medicine, Division of Gastroenterology, University of Alabama at Birmingham, AL, USA.

Mol Oncol ; 16(8): 1728-1745, 2022 04.

Article em En | MEDLINE | ID: mdl-35194944

Assuntos

Neoplasias Colorretais; beta Catenina; ATPases Associadas a Diversas Atividades Celulares/metabolismo; Animais; Proteínas de Ciclo Celular/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Neoplasias Colorretais/genética; Transição Epitelial-Mesenquimal; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos; NF-kappa B/metabolismo; Receptor Tipo 4 de Fator de Crescimento de Fibroblastos/metabolismo; Fator de Transcrição STAT3/metabolismo; Via de Sinalização Wnt; beta Catenina/metabolismo

Palavras-chave

DCZ0415; FGFR4; TRIP13; colorectal cancer; granzyme B; metastasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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