CYP2C19 Plays a Major Role in the Hepatic <i>N</i>-Oxidation of Cotinine.

Perez-Paramo, Yadira X; Watson, Christy J W; Chen, Gang; Lazarus, Philip

CYP2C19 Plays a Major Role in the Hepatic N-Oxidation of Cotinine.

Perez-Paramo, Yadira X; Watson, Christy J W; Chen, Gang; Lazarus, Philip.

Afiliação

Perez-Paramo YX; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Watson CJW; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Chen G; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Lazarus P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington phil.lazarus@wsu.edu.

Drug Metab Dispos ; 51(1): 29-37, 2023 01.

Article em En | MEDLINE | ID: mdl-35197312

Assuntos

Cotinina; Nicotina; Humanos; Cotinina/metabolismo; Nicotina/metabolismo; Citocromo P-450 CYP3A/metabolismo; Citocromo P-450 CYP2E1/metabolismo; Citocromo P-450 CYP2C19/genética; Citocromo P-450 CYP2C19/metabolismo; Cinética; Citocromo P-450 CYP2B6/metabolismo; Células HEK293; Sistema Enzimático do Citocromo P-450/metabolismo; Fígado/metabolismo; Microssomos Hepáticos/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article