Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition.

Mahnashi, Mater H; El-Senduny, Fardous F; Alshahrani, Mohammed Abdulrahman; Abou-Salim, Mahrous A

Mahnashi, Mater H; El-Senduny, Fardous F; Alshahrani, Mohammed Abdulrahman; Abou-Salim, Mahrous A.

Afiliação

Mahnashi MH; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 61441, Saudi Arabia.
El-Senduny FF; Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
Alshahrani MA; Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.
Abou-Salim MA; Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.

Pharmaceuticals (Basel) ; 15(2)2022 Feb 18.

Article em En | MEDLINE | ID: mdl-35215358

Palavras-chave

DAF-FM DA; MAPK; VEGFR-2; apoptosis; furoxan; metastasis; pyrazolo[3,4-d]pyrimidines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article