Network-based response module comprised of gene expression biomarkers predicts response to infliximab at treatment initiation in ulcerative colitis.

Ghiassian, Susan D; Voitalov, Ivan; Withers, Johanna B; Santolini, Marc; Saleh, Alif; Akmaev, Viatcheslav R

Ghiassian, Susan D; Voitalov, Ivan; Withers, Johanna B; Santolini, Marc; Saleh, Alif; Akmaev, Viatcheslav R.

Afiliação

Ghiassian SD; Scipher Medicine Corporation, Waltham MA.
Voitalov I; Scipher Medicine Corporation, Waltham MA.
Withers JB; Scipher Medicine Corporation, Waltham MA.
Santolini M; Center for Research and Interdisciplinarity (CRI), University Paris Descartes, Paris, France.
Saleh A; Scipher Medicine Corporation, Waltham MA.
Akmaev VR; Scipher Medicine Corporation, Waltham MA. Electronic address: slava.akmaev@sciphermedicine.com.

Transl Res ; 246: 78-86, 2022 08.

Article em En | MEDLINE | ID: mdl-35306220

Assuntos

Colite Ulcerativa; Anticorpos Monoclonais/uso terapêutico; Biomarcadores/metabolismo; Estudos de Coortes; Colite Ulcerativa/tratamento farmacológico; Colite Ulcerativa/genética; Humanos; Infliximab/genética; Infliximab/uso terapêutico; Transcriptoma; Resultado do Tratamento

Palavras-chave

TNF inhibitor; Ulcerative colitis; classifier; disease biology; gene expression; molecular signature

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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