Your browser doesn't support javascript.
loading
Tryptophan regulates Drosophila zinc stores.
Garay, Erika; Schuth, Nils; Barbanente, Alessandra; Tejeda-Guzmán, Carlos; Vitone, Daniele; Osorio, Beatriz; Clark, Adam H; Nachtegaal, Maarten; Haumann, Michael; Dau, Holger; Vela, Alberto; Arnesano, Fabio; Quintanar, Liliana; Missirlis, Fanis.
Afiliação
  • Garay E; Department of Physiology, Biophysics and Neuroscience, Cinvestav, 07360 Mexico City, Mexico.
  • Schuth N; Department of Chemistry, Cinvestav, 07360 Mexico City, Mexico.
  • Barbanente A; Department of Chemistry, University of Bari Aldo Moro, 70125 Bari, Italy.
  • Tejeda-Guzmán C; Department of Physiology, Biophysics and Neuroscience, Cinvestav, 07360 Mexico City, Mexico.
  • Vitone D; Department of Chemistry, University of Bari Aldo Moro, 70125 Bari, Italy.
  • Osorio B; Department of Physiology, Biophysics and Neuroscience, Cinvestav, 07360 Mexico City, Mexico.
  • Clark AH; Paul Scherrer Institute, CH-5232 Villigen, Switzerland.
  • Nachtegaal M; Paul Scherrer Institute, CH-5232 Villigen, Switzerland.
  • Haumann M; Department of Physics, Freie Universität Berlin, 14195 Berlin, Germany.
  • Dau H; Department of Physics, Freie Universität Berlin, 14195 Berlin, Germany.
  • Vela A; Department of Chemistry, Cinvestav, 07360 Mexico City, Mexico.
  • Arnesano F; Department of Chemistry, University of Bari Aldo Moro, 70125 Bari, Italy.
  • Quintanar L; Department of Chemistry, Cinvestav, 07360 Mexico City, Mexico.
  • Missirlis F; Department of Physiology, Biophysics and Neuroscience, Cinvestav, 07360 Mexico City, Mexico.
Proc Natl Acad Sci U S A ; 119(16): e2117807119, 2022 04 19.
Article em En | MEDLINE | ID: mdl-35412912
Zinc deficiency is commonly attributed to inadequate absorption of the metal. Instead, we show that body zinc stores in Drosophila melanogaster depend on tryptophan consumption. Hence, a dietary amino acid regulates zinc status of the whole insect­a finding consistent with the widespread requirement of zinc as a protein cofactor. Specifically, the tryptophan metabolite kynurenine is released from insect fat bodies and induces the formation of zinc storage granules in Malpighian tubules, where 3-hydroxykynurenine and xanthurenic acid act as endogenous zinc chelators. Kynurenine functions as a peripheral zinc-regulating hormone and is converted into a 3-hydroxykynurenine­zinc­chloride complex, precipitating within the storage granules. Thus, zinc and the kynurenine pathway­well-known modulators of immunity, blood pressure, aging, and neurodegeneration­are physiologically connected.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article