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Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Iannelli, Giulia; Milite, Ciro; Marechal, Nils; Cura, Vincent; Bonnefond, Luc; Troffer-Charlier, Nathalie; Feoli, Alessandra; Rescigno, Donatella; Wang, Yalong; Cipriano, Alessandra; Viviano, Monica; Bedford, Mark T; Cavarelli, Jean; Castellano, Sabrina; Sbardella, Gianluca.
Afiliação
  • Marechal N; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France.
  • Cura V; Centre National de la Recherche Scientifique, UMR7104 Illkirch, France.
  • Bonnefond L; Institut National de la Santé et de la Recherche Médicale, U1258 Illkirch, France.
  • Troffer-Charlier N; Université de Strasbourg, 67400 Illkirch, France.
  • Feoli A; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France.
  • Rescigno D; Centre National de la Recherche Scientifique, UMR7104 Illkirch, France.
  • Wang Y; Institut National de la Santé et de la Recherche Médicale, U1258 Illkirch, France.
  • Cipriano A; Université de Strasbourg, 67400 Illkirch, France.
  • Viviano M; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France.
  • Bedford MT; Centre National de la Recherche Scientifique, UMR7104 Illkirch, France.
  • Cavarelli J; Institut National de la Santé et de la Recherche Médicale, U1258 Illkirch, France.
  • Castellano S; Université de Strasbourg, 67400 Illkirch, France.
  • Sbardella G; Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France.
J Med Chem ; 65(17): 11574-11606, 2022 09 08.
Article em En | MEDLINE | ID: mdl-35482954
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article