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One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis.
Liu, Huan; Liu, Sensheng; Zhou, Haifeng; Liu, Qixing; Wang, Chunqin.
Afiliação
  • Liu H; Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China zhouhf@ctgu.edu.cn.
  • Liu S; Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China zhouhf@ctgu.edu.cn.
  • Zhou H; Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China zhouhf@ctgu.edu.cn.
  • Liu Q; Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China zhouhf@ctgu.edu.cn.
  • Wang C; Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China zhouhf@ctgu.edu.cn.
RSC Adv ; 8(27): 14829-14832, 2018 Apr 18.
Article em En | MEDLINE | ID: mdl-35541341
ABSTRACT
A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF3SO3H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF3CH2OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article