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Electrochemical and In Vitro Biological Evaluation of Bio-Active Coatings Deposited by Magnetron Sputtering onto Biocompatible Mg-0.8Ca Alloy.
Bița, Ana-Iulia; Antoniac, Iulian; Miculescu, Marian; Stan, George E; Leonat, Lucia; Antoniac, Aurora; Constantin, Bujor; Forna, Norin.
Afiliação
  • Bița AI; Department of Metallic Materials Science and Physical Metallurgy, Materials Science and Engineering Faculty, University Politehnica of Bucharest, 060042 București, Romania.
  • Antoniac I; Department of Metallic Materials Science and Physical Metallurgy, Materials Science and Engineering Faculty, University Politehnica of Bucharest, 060042 București, Romania.
  • Miculescu M; Department of Metallic Materials Science and Physical Metallurgy, Materials Science and Engineering Faculty, University Politehnica of Bucharest, 060042 București, Romania.
  • Stan GE; National Institute of Materials Physics, 405A Atomistilor Street, 077125 Magurele, Romania.
  • Leonat L; National Institute of Materials Physics, 405A Atomistilor Street, 077125 Magurele, Romania.
  • Antoniac A; Department of Metallic Materials Science and Physical Metallurgy, Materials Science and Engineering Faculty, University Politehnica of Bucharest, 060042 București, Romania.
  • Constantin B; Department of Quality Engineering and Industrial Technologies, Industrial Engineering and Robotics Faculty, University Politehnica of Bucharest, 060042 București, Romania.
  • Forna N; Department of Orthopedics and Traumatology, University of Medicine and Pharmacy Gr.T.Popa Iasi, 16 University Str., 700115 Iasi, Romania.
Materials (Basel) ; 15(9)2022 Apr 25.
Article em En | MEDLINE | ID: mdl-35591436
The use of resorbable magnesium alloys in the design of implants represents a new direction in the healthcare domain. Two main research avenues are currently explored for developing or improving metallic biomaterials: (i) increase of their corrosion resistance by designed compositional and structural modifications, and (ii) functionalization of their surfaces by coating with ceramic or polymeric layers. The main objective of this work was to comparatively assess bio-functional coatings (i.e., highly-crystallized hydroxyapatite and silica-rich glass) deposited by radio-frequency magnetron sputtering (RF-MS) on a biodegradable Mg-0.8Ca alloy (0.8 wt.% of Ca). After probing their morphology (by scanning electron microscopy) and structure (by Fourier transform infrared spectroscopy and grazing incidence X-ray diffraction), the corrosion resistance of the RF-MS coated Mg-0.8Ca substrates was electrochemically tested (in synthetic biological media with different degrees of biomimicry), and their cytocompatibility was assessed in osteoblast and fibroblast cell cultures. By collective assessment, the most promising performances, in terms of mass loss (~7% after 12 days), hydrogen release rate (~6 mL/cm2 after 12 days), electrochemical corrosion parameters and cytocompatibility, were obtained for the crystalline HA coating.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article