Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels.

Ong, Seow Theng; Tyagi, Anu; Chandy, K George; Bhushan, Shashi

Ong, Seow Theng; Tyagi, Anu; Chandy, K George; Bhushan, Shashi.

Afiliação

Ong ST; LKCMedicine-ICESing Ion Channel Platform, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Tyagi A; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Chandy KG; Singapore and Nanyang Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore.
Bhushan S; LKCMedicine-ICESing Ion Channel Platform, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Front Pharmacol ; 13: 924289, 2022.

Article em En | MEDLINE | ID: mdl-35833027

Palavras-chave

C-type inactivation; Kv1.3; Shaker-IR; cryo-EM; dalazatide; hydrogen bond network; slow inactivation; voltage-gated potassium (Kv) channels

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article